S7-1.1.2 Jan. 6 The Ionic Mechanism Underlying Postinhibitory Rebound in Clione limacina Swim Interneurons PIRTLE, T.J.*; SATTERLIE, R.A.; Abilene Christian University ; Univ. North Carolina, Wilmington Thomas.Pirtle@acu.edu
Swimming locomotion in Clione limacina is produced by alternate dorsal-ventral flexions of its wing-like parapodia which are ultimately controlled by two groups of pedal interneurons that interact via reciprocal inhibition, forming a fairly simple central pattern generator (swim CPG). One cellular property that is important for rhythmic pattern generation is postinhibitory rebound. Serotonergic enhancement of postinhibitory rebound amplitude has been shown to participate in swim acceleration. Here we describe the ionic mechanisms underlying postinhibitory rebound in swim CPG interneurons. Single electrode voltage clamp and current clamp experiments reveal that both calcium and sodium conductances contribute to postinhibitory rebound in Clione swim interneurons.