Meeting Abstract

S4-2.2  Jan. 5  Comprehensive modelling of the immune response of cytotoxic T Lymphocytes in the influenza infection TRIDANE, A*; HADELER, K; KUANG, Y; Arizona State University; Arizona State University; Arizona State University

The aim of this work is to investigate the mechanisms involved in the clearance of viral infection of the influenza virus at the epithelium level by analyzing the interaction of the influenza virus-specific cytotoxic T Lymphocytes (CTL) and the epithelial cells . In fact, the understanding of this interaction would provide us interesting tools for the evaluation of the potential protective cell-mediated immunity. Moreover, the induction of CTL-cells by vaccination is considered to be highly desirable, particularly in the context of viral infections, such as influenza, where the surface glycoproteins of the virus rapidly accumulate amino acid substitutions that allow the virus to escape from pre-existing antibody responses. By presenting different scenarios of interaction of CTL-cells and epithelial cells, we constructed models of CTL response to influenza infection. Our ultimate goal is to use these models to provide insight into the pathology and possible treatment of this disease.